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SCREENING OF MEDICAL PLANTS FOR THEIR INHIBITORY ACTIVITY AGAINST THE ENZYMES NEP AND ACE Oleski, A.1; Melzig, M.1; Lindequist, U.2 1Institut fr Pharmazie, Freie Univ. Berlin, D-14195 Berlin, Germany 2Institut fr Pharmazie, Univ. Greifswald, D-17489 Greifswald, Germany The methanolic extracts of 20 yemeni medical plants from the island of Socotra were screened for their inhibitory activity against the enzymes neutral endopeptidase NEP, EC 3.4.24.11 ; , angiotensin-converting-enzyme ACE, EC 3.4.15.1 ; and leucine-aminopeptidase LAP, EC 3.4.11.2 ; . These enzymes belonging to the metallopeptidase-family play important roles in several physiological processes in the human body. Beside the degradation of regulatory peptides they play an important role in the pathogenesis of various diseases. Eight of the methanolic extracts showed no relevant enzyme-inhibition in the concentration up to 400 g ml. Three plants inhibited all selected enzymes: Kalanchoe farinacea, Cissus hamadorensis and Boswellia elongata. Pulicaria stephanocarpa, Jatropha unicostata and Exacum affine displayed beside an inhibitory acitvity against NEP also one against ACE. Boswellia ameero und Gnidia socotrana showed a simultaneous inhibition of NEP and LAP. The plant extracts which showed an activity against LAP, also showed one against at least one of the other enzymes. Exclusively NEP-inhibiting methanolic extracts were those of Cissus subaphylla, Dracaena cinnabari, Fagonia luntii and the bark of Jatropha unicostata. The IC50 values of these four extracts in the NEPinhibition were rather high. The most effective enzyme inhibition showed Kalanchoe farinacea, which had an IC50 of 7 g ml for NEP, 87 g ml for ACE and 2 g ml for LAP. The results of all enzyme tests display a higher potential in the inhibition of NEP than of ACE. A further investigation of Kalanchoe farinacea, Cissus hamadorensis, Boswellia elongata and Boswellia ameero after the isolation and characterization of their compounds could be a possibility for the finding of new inhibitors of metallopeptidases.
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Leadership Award ceremoniously handed over to him jointly by the industry leaders. Reliance plasma proteins made its mark as the BioSpectrum Product of the Year. BioSpectrum Bureau. Including minor ranges to the north ; Map showing Cordillera Huaytapallana This name covers a rather diffuse and varied number of peaks which are contained, roughly speaking, within the area 1130'-1200'S by 7445'-7515'W. The principal part of this mountain system lies c.25 km north-east of the town of Huancayo, the usual approach being via Hacienda Acopalca on the road from Huancayo to the fertile Parihuanca valley. About one and a half hours' drive above Acopalca, at the top of the Huaytapallana Pass, a 2-hour walk leads to the glacier basins of Lasontay and its neighbouring peaks. The main range of snow peaks runs in a N.W. - S.E. direction and is about twenty kilometres long. Some twenty kilometres to the east, on the other side of the deeply cut Pariahuanca valley, are four small snow massifs which are known as the Huaytapallana Karu. An area of lesser peaks lies to the north of the main range, principally in the vicinity of the towns of Comas and Runatullo. The prevailing moist east wind gives rise to a great deal of precipitation, building up big glaciers and crevasses, as well as large cornices on the ridges and summits, while Lasontay gets its name `Smoking Ice' ; from its wind-blown plumes. The snow line on the drier western side is c.4800 metres. One of the first travellers through the area was Raimondi who crossed the Huaytapallana Pass in 1866. He called the range Cordillera de Huaritanga. The first modern geographer to study the range was Dr. Hans Kinzl, whose 1939 expedition camped by Lago Lasontay during the first part of their photo survey of the glaciated areas. At the beginning of June 1946 the Swiss geologist Arnold Heim spent two days examining the Lasontay area. From the Huaytapallana Pass his party traversed northwest along rock walls and snow patches to the foot of a small hanging glacier, where a cairn was built as a survey point. Meanwhile Heim and a companion climbed steep snow to a height of 5300 metres in an effort to obtain good photographs. To the north Lasontay was already covered by the day's cloud so they glissaded down to the emerald-green lake at the foot of its south-western glaciers. Next. Medical surveillance also applies to workers exposed to other aliphatic nitrate explosives. How long till diflucan worksREFERENCE PERSON: Jerry Cade, MD, Infectious Diseases REFERENCES: Center for Disease Control. 1999. Prevention and Management of Opportunistic Infections in HIV-Infected Adults and Adolescents. Atlanta, GA: CDC. Center for Disease Control. 1998. Report to the NIH panel to define principles of therapy of HIV infection. Atlanta, GA: CDC. Barlett, J. & Gallant, J. 2001 ; . Medical management of HIV infection, 2001-2002. Baltimore, MD: John Hopkins University Press Phar, J. 2001 ; . Northwestern University Medical School. Comprehensive AIDS Center. HIV IDS annual update 2001. Milford, MA: iMedOptions, LLC. U.S. Department of Health and Human Services. 2001 ; . Guidelines for the use of antiretroviral agens in HIV-infected adults and adolescents. Washington DC: USDHHS and HIV AIDS Treatment Service atis. Home about blog sign up log in communities local resources a 360° view of arthrotec side effects sections in the mix local resources blogs news trusted sources web results more wellmix 360 pages: couch care couch massage cough ribs coulomb friction coumadin 5 coumadin and diet coumadin antidote coumadin cranberry juice coumadin guidelines coumadin long term coumadin stroke coumadin testing counseling palm counter diflucan countryside montessori school cozaar blood pressure cozaar com cr 240 cracker barrel rest creamy horseradish sauce local resources related to arthrotec side effects no related resources. Diflucan resistanceDiflucan pediatric doseDiflucan gluten freeCiflucan, d8flucan, diflufan, diflhcan, difluan, diflucah, divlucan, diflucann, difluccan, diflucxn, difluacn, dilucan, dilfucan, doflucan, diclucan, xiflucan, didlucan, difl7can, diflucab, dflucan, djflucan, diflkcan, riflucan, difluvan, diflucna, difkucan, dirlucan, dfilucan, difoucan, difluca, ditlucan, diflucwn.Yeast infection diflucan for menDiflucan and candida albicans, diflucan 2 doses, diflucan yeast dose, how long till diflucan works and diflucan resistance. Diflucan pediatric dose, diflucan gluten free, yeast infection diflucan for men and systemic candida diflucan or diflucan antibiotics. Systemic candida diflucanCreatinine clearance test method, selenium 74, focal seizure activity in the left temporal lobe, serving size glass of wine and hallux rigidus big toe. Toprol tachycardia, central auditory processing disorder validity, bradycardia symptoms heart rate and epitope peptide or zomig sales. © 2009 |